Immunity to Influenza in Ferrets X. Intranasal Immunization of Ferrets with Inactivated Influenza A Virus Vaccines
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چکیده
منابع مشابه
Heterotypic immunity to influenza in ferrets.
Heterotypic immunity to influenza virus in ferrets operated against heterotypic influenza viruses but not heterologous viruses. Contrary to prior reports, the protection conferred lasted for at least 18 months. This type of immunity limited virus shedding but did not prevent infection. These results suggest that this phenomenon could play a role in determining the severity of infections caused ...
متن کاملLocal and systemic immunity to influenza infections in ferrets.
To establish whether immunity to influenza infection in the ferret is local or systemic, two sites of challenge were utilized: the nose and the anatomically isolated tracheal pouch. Infection of either site did not spread to the other site, and challenge of either site resulted in seroconversion by 13 days. Simultaneous challenge of both sites 21 days after the primary infection revealed that p...
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High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...
متن کاملThe Infection of Ferrets with Swine Influenza Virus
The experiments described confirm the earlier observation of Smith, Andrewes, and Laidlaw that the swine influenza virus is pathogenic for ferrets when administered intranasally. A disease that is clinically more severe and pathologically more extensive than that described by the above workers is obtained if inoculation with the virus is performed under ether anesthesia. Animals infected in thi...
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The recovery of a filtrable virus from children with influenza has been described in other papers" T,the virus was isolated by means of the intranasal inoculation of ferrets with nasopharyngeal washings. The ferrets reacted to the washings with an acute respiratory infection, followed by recovery. After the virus had been transmitted in series through ferrets for' several generations, the react...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1974
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.9.6.985-990.1974